Allosteric conformational changes of human HBV core protein transform its assembly

Allosteric conformational changes of human HBV core protein transform its assembly

Abstract Hepatitis B Virus core protein (HBc) has multiple roles in the viral lifecycle: viral assembly, compartment for reverse transcription, intracellular trafficking, and nuclear functions. HBc displays assembly polymorphism - it can assemble into icosahedral capsid and aberrant non-capsid struc...

Full description

Bibliographic Details
Main Authors:	Chuang Liu, Guizhen Fan, Zhao Wang, Hong-Song Chen, Chang-Cheng Yin
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-05-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-017-01568-9

Similar Items

Computation of conformational coupling in allosteric proteins.
by: Brian A Kidd, et al.
Published: (2009-08-01)

HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways.
by: Fang Guo, et al.
Published: (2017-09-01)

HBV Core Protein Enhances Cytokine Production
by: Tatsuo Kanda, et al.
Published: (2015-09-01)

Subunit conformation during the allosteric transitions in hemoglobin
by: Maeda, Toyozo
Published: (2017)

Conformational transition pathway in the activation process of allosteric glucokinase.
by: Min Huang, et al.
Published: (2013-01-01)

Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding
by: Rebecca Beveridge, et al.
Published: (2016-07-01)

The Allosteric Regulation of c-di-AMP and ATP on the Conformational Change of KtrA
by: Wesley-Tien Chiang, et al.
Published: (2017)

Effect of the HBV Capsid Assembly Inhibitor Bayer 41-4109 on the Intracellular Localization of EGFP-Core Fusion Proteins
by: Aris Haryanto, et al.
Published: (2015-11-01)

Effect of the HBV Capsid Assembly Inhibitor Bayer 41-4109 on the Intracellular Localization of EGFP-Core Fusion Proteins
by: Aris Haryanto, et al.
Published: (2007-12-01)

Characterization and Application of HBV Core-Pol Fusion Proteins
by: chen, kun-lin, et al.
Published: (2001)

Engineering protein assemblies with allosteric control via monomer fold-switching
by: Luis A. Campos, et al.
Published: (2019-12-01)

Uncoupling conformational states from activity in an allosteric enzyme
by: João P. Pisco, et al.
Published: (2017-08-01)

Allosteric conformational change cascade in cytoplasmic dynein revealed by structure-based molecular simulations.
by: Shintaroh Kubo, et al.
Published: (2017-09-01)

Allosteric communication in myosin V: from small conformational changes to large directed movements.
by: M Cecchini, et al.
Published: (2008-01-01)

Inhibition of the HCV core protein on the immune response to HBV surface antigen and on HBV gene expression and replication in vivo.
by: Wenbo Zhu, et al.
Published: (2012-01-01)

Caspase-7 loop conformations as a means of allosteric control
by: Witkowski, Witold A
Published: (2011)

Caspase-7 Loop Conformations as a Means of Allosteric Control
by: Witkowski, Witold Andrej
Published: (2011)

Allosteric conformational ensembles have unlimited capacity for integrating information
by: John W Biddle, et al.
Published: (2021-06-01)

An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes
by: Antonia A. Nemec, et al.
Published: (2019-01-01)

Conformational dynamics of supramolecular protein assemblies
by: Kim, Do-Nyun, et al.
Published: (2017)

Induction of innate immunity by HBV core protein in mouse animal model
by: Ying-Chao Hsueh, et al.
Published: (2012)

Studies on Phosphoenolpyruvate Carboxylase of Escherichia coli : Multiple Conformational States Elicited by the Allosteric Effectors and Structural Specificity of the Allosteric Inhibitor
by: Yoshinaga, Takeo
Published: (2017)

Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design
by: Shaoyong Lu, et al.
Published: (2021-08-01)

DNA immunization with fusion of CTLA-4 to hepatitis B virus (HBV) core protein enhanced Th2 type responses and cleared HBV with an accelerated kinetic.
by: Ying Yin, et al.
Published: (2011-01-01)

PEA-15 C-Terminal Tail Allosterically Modulates Death-Effector Domain Conformation and Facilitates Protein–Protein Interactions
by: Sergio L. Crespo-Flores, et al.
Published: (2019-07-01)

Coherent conformational degrees of freedom as a structural basis for allosteric communication.
by: Simon Mitternacht, et al.
Published: (2011-12-01)

Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift
by: Verena Peters, et al.
Published: (2017-01-01)

Conformational dynamics data bank: a database for conformational proteins and supramolecular protein assemblies
by: Kim, Do-Nyun, et al.
Published: (2011)

EFFECTS OF MUTATED CORE PROTEINS ON HEPATITIS B VIRUS (HBV) PARTICLE MATURATION
by: Eric Ka-Wai Hui, et al.
Published: (1999)

Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids
by: Christopher John Schlicksup, et al.
Published: (2018-01-01)

Identifying allosteric fluctuation transitions between different protein conformational states as applied to Cyclin Dependent Kinase 2
by: Gu Jenny, et al.
Published: (2007-02-01)

Silane Modulation of Protein Conformation and Self-Assembly
by: Giasuddin, Abul Bashar Mohammad
Published: (2018)

Modulation of calmodulin lobes by different targets: an allosteric model with hemiconcerted conformational transitions.
by: Massimo Lai, et al.
Published: (2015-01-01)

Computational Insights into Allosteric Conformational Modulation of P-Glycoprotein by Substrate and Inhibitor Binding
by: Juan Xing, et al.
Published: (2020-12-01)

Allosteric inhibition explained through conformational ensembles sampling distinct “mixed” states
by: Jung Ah Byun, et al.
Published: (2020-01-01)

Modification of local and global conformational stability of hemoglobin by the allosteric effectors BPG and IHP
by: Ali, Md. Eaqub
Published: (2004)

Identification of the Putative Kinase for Serine-170 in C-terminal Domain of HBV Core Protein
by: Rou-Chen Liu, et al.
Published: (2016)

Protein structure and conformational changes studied by Fourier transform infrared spectroscopy
by: Hadden, Jonathan Mark
Published: (1995)

The genotype‐phenotype landscape of an allosteric protein
by: Drew S Tack, et al.
Published: (2021-03-01)

Conformational rearrangement of the NMDA receptor amino-terminal domain during activation and allosteric modulation
by: Vojtech Vyklicky, et al.
Published: (2021-05-01)