Effect of γ-secretase inhibitor on Th17 cell differentiation and function of mouse psoriasis-like skin inflammation

Effect of γ-secretase inhibitor on Th17 cell differentiation and function of mouse psoriasis-like skin inflammation

Abstract Background Th17 cells and its effective cytokine IL-17A play an important role in the pathogenesis of abnormal immune responses in psoriasis. Notch1 signaling has been implicated in Th17 cell differentiation and function. In this study, our aim was to evaluate the possible inhibitory effect...

Full description

Bibliographic Details
Main Authors: Lei Ma, Haibo Xue, Ruiqun Qi, Yanqin Wang, Libing Yuan
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Translational Medicine
Subjects:
Psoriasis
Notch1 signaling
Th17 cells
γ-secretase inhibitor
Online Access:http://link.springer.com/article/10.1186/s12967-018-1442-6

Similar Items

Similar Items