Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis.

Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis.

BACKGROUND: Sepsis is associated with systemic inflammatory responses and induction of coagulation system. Neutrophil extracellular traps (NETs) constitute an antimicrobial mechanism, recently implicated in thrombosis via platelet entrapment and aggregation. METHODOLOGY/PRINCIPAL FINDINGS: In this s...

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Main Authors: Konstantinos Kambas, Ioannis Mitroulis, Eirini Apostolidou, Andreas Girod, Akrivi Chrysanthopoulou, Ioannis Pneumatikos, Panagiotis Skendros, Ioannis Kourtzelis, Maria Koffa, Ioannis Kotsianidis, Konstantinos Ritis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3446899?pdf=render

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http://europepmc.org/articles/PMC3446899?pdf=render

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