Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking

• Main Authors: Behrensmeier Frank, Madlung Axel, Tille Jan, Bigler Roland, Manser Peter, Vetterli Daniel, Vock Jacqueline, Ghadjar Pirus, Mini Roberto, Aebersold Daniel M
• Format: Article
• Language: English
• Published: BMC 2008-10-01
• Series: Radiation Oncology
• Online Access: http://www.ro-journal.com/content/3/1/35

<p>Abstract</p> <p>Background</p> <p>To report acute and late toxicity in prostate cancer patients treated by dose escalated intensity-modulated radiation therapy (IMRT) and organ tracking.</p> <p>Methods</p> <p>From 06/2004 to 12/2005 39 men were treated by 80 Gy IMRT along with organ tracking. Median age was 69 years, risk of recurrence was low 18%, intermediate 21% and high in 61% patients. Hormone therapy (HT) was received by 74% of patients. Toxicity was scored according to the CTC scale version 3.0. Median follow-up (FU) was 29 months.</p> <p>Results</p> <p>Acute and maximal late grade 2 gastrointestinal (GI) toxicity was 3% and 8%, late grade 2 GI toxicity dropped to 0% at the end of FU. No acute or late grade 3 GI toxicity was observed. Grade 2 and 3 pre-treatment genitourinary (GU) morbidity (PGUM) was 20% and 5%. Acute and maximal late grade 2 GU toxicity was 56% and 28% and late grade 2 GU toxicity decreased to 15% of patients at the end of FU. Acute and maximal late grade 3 GU toxicity was 8% and 3%, respectively. Decreased late ≥ grade 2 GU toxicity free survival was associated with higher age (P = .025), absence of HT (P = .016) and higher PGUM (P < .001).</p> <p>Discussion</p> <p>GI toxicity rates after IMRT and organ tracking are excellent, GU toxicity rates are strongly related to PGUM.</p>