Applicability of Traditional In Vitro Toxicity Tests for Assessing Adverse Effects of Monoclonal Antibodies: A Case Study of Rituximab and Trastuzumab

Applicability of Traditional In Vitro Toxicity Tests for Assessing Adverse Effects of Monoclonal Antibodies: A Case Study of Rituximab and Trastuzumab

Monoclonal antibody (mAb) therapeutics have a promising outlook within the pharmaceutical industry having made positive strides in both research and development as well as commercialisation, however this development has been hampered by manufacturing failures and attrition. This study explores the a...

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Bibliographic Details
Main Authors: Arathi Kizhedath, Simon Wilkinson, Jarka Glassey
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Antibodies
Subjects:
biopharmaceutical development
in vitro tests
off target toxicity
developability
traditional testing
monoclonal antibodies
Online Access:http://www.mdpi.com/2073-4468/7/3/30

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