Clustered Protocadherins Are Required for Building Functional Neural Circuits

Clustered Protocadherins Are Required for Building Functional Neural Circuits

Neuronal identity is generated by the cell-surface expression of clustered protocadherin (Pcdh) isoforms. In mice, 58 isoforms from three gene clusters, Pcdhα, Pcdhβ, and Pcdhγ, are differentially expressed in neurons. Since cis-heteromeric Pcdh oligomers on the cell surface interact homophilically...

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Bibliographic Details
Main Authors: Takeshi Yagi, Sonoko Hasegawa, Hiroaki Kobayashi, Makiko Kumagai, Hiroshi Nishimaru, Etsuko Tarusawa, Hiro Kanda, Makoto Sanbo, Yumiko Yoshimura, Masumi Hirabayashi, Takahiro Hirabayashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
genome engineering
synapse
synchronous activity
homophilic interaction
locomotion
brainstem reticular formation
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00114/full

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