Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations

Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations

Lipoprotein cholesterol taken up by cells is processed in the endosomal/lysosomal (E/L) compartment by the sequential action of lysosomal acid lipase (LAL), Niemann-Pick C2 (NPC2), and Niemann-Pick C1 (NPC1). Inactivation of NPC2 in mouse caused sequestration of unesterified cholesterol (UC) and exp...

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Bibliographic Details
Main Authors:	Charina M. Ramirez, Benny Liu, Amal Aqul, Anna M. Taylor, Joyce J. Repa, Stephen D. Turley, John M. Dietschy
Format:	Article
Language:	English
Published:	Elsevier 2011-04-01
Series:	Journal of Lipid Research
Subjects:	Niemann-Pick type C disease Wolman disease liver disease neurodegeneration macrophage inflammation
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520409034

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