Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes

Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes

This review discusses the current understanding of cysteine and glutathione redox balance in astrocytes. Particular emphasis is placed on the impact of oxidative stress and astrocyte activation on pathways that provide cysteine as a precursor for glutathione. The effect of the disruption of thiol-co...

Full description

Bibliographic Details
Main Author: Gethin J. McBean
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Antioxidants
Subjects:
cysteine
cystine
cysteamine
cystathionine
glutathione
xc− cystine-glutamate exchanger
transsulfuration
Online Access:https://www.mdpi.com/2076-3921/6/3/62
id doaj-dd712267e9ad4b129a55b05fbca5a66a
record_format Article
spelling doaj-dd712267e9ad4b129a55b05fbca5a66a2020-11-24T23:12:21ZengMDPI AGAntioxidants2076-39212017-08-01636210.3390/antiox6030062antiox6030062Cysteine, Glutathione, and Thiol Redox Balance in AstrocytesGethin J. McBean0School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, IrelandThis review discusses the current understanding of cysteine and glutathione redox balance in astrocytes. Particular emphasis is placed on the impact of oxidative stress and astrocyte activation on pathways that provide cysteine as a precursor for glutathione. The effect of the disruption of thiol-containing amino acid metabolism on the antioxidant capacity of astrocytes is also discussed.https://www.mdpi.com/2076-3921/6/3/62cysteinecystinecysteaminecystathionineglutathionexc− cystine-glutamate exchangertranssulfuration
collection DOAJ
language English
format Article
sources DOAJ
author Gethin J. McBean
spellingShingle Gethin J. McBean
Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes
Antioxidants
cysteine
cystine
cysteamine
cystathionine
glutathione
xc− cystine-glutamate exchanger
transsulfuration
author_facet Gethin J. McBean
author_sort Gethin J. McBean
title Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes
title_short Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes
title_full Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes
title_fullStr Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes
title_full_unstemmed Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes
title_sort cysteine, glutathione, and thiol redox balance in astrocytes
publisher MDPI AG
series Antioxidants
issn 2076-3921
publishDate 2017-08-01
description This review discusses the current understanding of cysteine and glutathione redox balance in astrocytes. Particular emphasis is placed on the impact of oxidative stress and astrocyte activation on pathways that provide cysteine as a precursor for glutathione. The effect of the disruption of thiol-containing amino acid metabolism on the antioxidant capacity of astrocytes is also discussed.
topic cysteine
cystine
cysteamine
cystathionine
glutathione
xc− cystine-glutamate exchanger
transsulfuration
url https://www.mdpi.com/2076-3921/6/3/62
work_keys_str_mv AT gethinjmcbean cysteineglutathioneandthiolredoxbalanceinastrocytes
_version_ 1725601194572775424

Similar Items