Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea

Abstract Background Obstructive sleep apnea (OSA) is a sleep-related disorder with breathing difficulties. Previous studies revealed that epicardial fat thickness (EFT) correlates with OSA severity. Interestingly, female patients display a stronger EFT-OSA correlation than males. The purpose of this...

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Main Authors: Yong Zhang, Jian Wang, Wen Shui, Zhenxia Zhang, Juan Li, Jin Ma
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Women's Health
Subjects:
Online Access:https://doi.org/10.1186/s12905-021-01384-4
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spelling doaj-dd6ef20609654702a7bad19f77c93d9f2021-06-13T11:24:56ZengBMCBMC Women's Health1472-68742021-06-012111810.1186/s12905-021-01384-4Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apneaYong Zhang0Jian Wang1Wen Shui2Zhenxia Zhang3Juan Li4Jin Ma5Medical Imaging College, Shanxi Medical UniversityDepartment of Ultrasound, First Hospital of Shanxi Medical UniversityMedical Imaging College, Shanxi Medical UniversityDepartment of Respiratory, First Hospital of Shanxi Medical UniversityMedical Imaging College, Shanxi Medical UniversityMedical Imaging College, Shanxi Medical UniversityAbstract Background Obstructive sleep apnea (OSA) is a sleep-related disorder with breathing difficulties. Previous studies revealed that epicardial fat thickness (EFT) correlates with OSA severity. Interestingly, female patients display a stronger EFT-OSA correlation than males. The purpose of this study is to investigate the relationship between EFT and different clinical characteristics in pre- and post-menopausal women diagnosed with OSA. Methods Patients diagnosed with OSA were divided into pre/early peri-menopausal (Group 1) and post/late peri-menopausal (Group 2) according to the menopause status. EFT was obtained from parasternal long-axis echocardiographic images. We also collected general clinical characteristics of patients involved in this study, and performed spearman correlation analysis to explore the correlations between EFT and the general clinical characteristics. We further applied Multiple stepwise linear regression analysis to explore the predictors for EFT in both groups. Results A total number of 23 and 59 patients were enrolled in Group 1 and Group 2 respectively. EFT in Group 2 was significantly higher than that of Group 1. In both groups, EFT was positively correlated with apnea–hypopnea index (AHI), percentage of total sleep time when blood oxygen saturation was less than 90% (T90), oxygen desaturation index (ODI) and glucose; while EFT was negatively correlated with mean and lowest SaO2 (oxygen saturation) levels. However, EFT was positively correlated with total cholesterol (TC) only in Group 1 and body mass index (BMI) only in Group2, respectively. Multiple stepwise linear regression analysis showed that AHI was independently associated with EFT in Group 1. However, both AHI and BMI were independent predictors of EFT in Group 2. Conclusion EFT was notably correlated with menopausal status in women with OSA. AHI was the independent predictor of EFT in women with OSA. BMI was the independent predictor of EFT in post/late peri-menopausal women with OSA.https://doi.org/10.1186/s12905-021-01384-4Obstructive sleep apneaMenopausalEpicardial fat thicknessApnea–hypopnea indexBody mass index
collection DOAJ
language English
format Article
sources DOAJ
author Yong Zhang
Jian Wang
Wen Shui
Zhenxia Zhang
Juan Li
Jin Ma
spellingShingle Yong Zhang
Jian Wang
Wen Shui
Zhenxia Zhang
Juan Li
Jin Ma
Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea
BMC Women's Health
Obstructive sleep apnea
Menopausal
Epicardial fat thickness
Apnea–hypopnea index
Body mass index
author_facet Yong Zhang
Jian Wang
Wen Shui
Zhenxia Zhang
Juan Li
Jin Ma
author_sort Yong Zhang
title Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea
title_short Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea
title_full Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea
title_fullStr Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea
title_full_unstemmed Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea
title_sort different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea
publisher BMC
series BMC Women's Health
issn 1472-6874
publishDate 2021-06-01
description Abstract Background Obstructive sleep apnea (OSA) is a sleep-related disorder with breathing difficulties. Previous studies revealed that epicardial fat thickness (EFT) correlates with OSA severity. Interestingly, female patients display a stronger EFT-OSA correlation than males. The purpose of this study is to investigate the relationship between EFT and different clinical characteristics in pre- and post-menopausal women diagnosed with OSA. Methods Patients diagnosed with OSA were divided into pre/early peri-menopausal (Group 1) and post/late peri-menopausal (Group 2) according to the menopause status. EFT was obtained from parasternal long-axis echocardiographic images. We also collected general clinical characteristics of patients involved in this study, and performed spearman correlation analysis to explore the correlations between EFT and the general clinical characteristics. We further applied Multiple stepwise linear regression analysis to explore the predictors for EFT in both groups. Results A total number of 23 and 59 patients were enrolled in Group 1 and Group 2 respectively. EFT in Group 2 was significantly higher than that of Group 1. In both groups, EFT was positively correlated with apnea–hypopnea index (AHI), percentage of total sleep time when blood oxygen saturation was less than 90% (T90), oxygen desaturation index (ODI) and glucose; while EFT was negatively correlated with mean and lowest SaO2 (oxygen saturation) levels. However, EFT was positively correlated with total cholesterol (TC) only in Group 1 and body mass index (BMI) only in Group2, respectively. Multiple stepwise linear regression analysis showed that AHI was independently associated with EFT in Group 1. However, both AHI and BMI were independent predictors of EFT in Group 2. Conclusion EFT was notably correlated with menopausal status in women with OSA. AHI was the independent predictor of EFT in women with OSA. BMI was the independent predictor of EFT in post/late peri-menopausal women with OSA.
topic Obstructive sleep apnea
Menopausal
Epicardial fat thickness
Apnea–hypopnea index
Body mass index
url https://doi.org/10.1186/s12905-021-01384-4
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