Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea
Abstract Background Obstructive sleep apnea (OSA) is a sleep-related disorder with breathing difficulties. Previous studies revealed that epicardial fat thickness (EFT) correlates with OSA severity. Interestingly, female patients display a stronger EFT-OSA correlation than males. The purpose of this...
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doaj-dd6ef20609654702a7bad19f77c93d9f2021-06-13T11:24:56ZengBMCBMC Women's Health1472-68742021-06-012111810.1186/s12905-021-01384-4Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apneaYong Zhang0Jian Wang1Wen Shui2Zhenxia Zhang3Juan Li4Jin Ma5Medical Imaging College, Shanxi Medical UniversityDepartment of Ultrasound, First Hospital of Shanxi Medical UniversityMedical Imaging College, Shanxi Medical UniversityDepartment of Respiratory, First Hospital of Shanxi Medical UniversityMedical Imaging College, Shanxi Medical UniversityMedical Imaging College, Shanxi Medical UniversityAbstract Background Obstructive sleep apnea (OSA) is a sleep-related disorder with breathing difficulties. Previous studies revealed that epicardial fat thickness (EFT) correlates with OSA severity. Interestingly, female patients display a stronger EFT-OSA correlation than males. The purpose of this study is to investigate the relationship between EFT and different clinical characteristics in pre- and post-menopausal women diagnosed with OSA. Methods Patients diagnosed with OSA were divided into pre/early peri-menopausal (Group 1) and post/late peri-menopausal (Group 2) according to the menopause status. EFT was obtained from parasternal long-axis echocardiographic images. We also collected general clinical characteristics of patients involved in this study, and performed spearman correlation analysis to explore the correlations between EFT and the general clinical characteristics. We further applied Multiple stepwise linear regression analysis to explore the predictors for EFT in both groups. Results A total number of 23 and 59 patients were enrolled in Group 1 and Group 2 respectively. EFT in Group 2 was significantly higher than that of Group 1. In both groups, EFT was positively correlated with apnea–hypopnea index (AHI), percentage of total sleep time when blood oxygen saturation was less than 90% (T90), oxygen desaturation index (ODI) and glucose; while EFT was negatively correlated with mean and lowest SaO2 (oxygen saturation) levels. However, EFT was positively correlated with total cholesterol (TC) only in Group 1 and body mass index (BMI) only in Group2, respectively. Multiple stepwise linear regression analysis showed that AHI was independently associated with EFT in Group 1. However, both AHI and BMI were independent predictors of EFT in Group 2. Conclusion EFT was notably correlated with menopausal status in women with OSA. AHI was the independent predictor of EFT in women with OSA. BMI was the independent predictor of EFT in post/late peri-menopausal women with OSA.https://doi.org/10.1186/s12905-021-01384-4Obstructive sleep apneaMenopausalEpicardial fat thicknessApnea–hypopnea indexBody mass index |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yong Zhang Jian Wang Wen Shui Zhenxia Zhang Juan Li Jin Ma |
spellingShingle |
Yong Zhang Jian Wang Wen Shui Zhenxia Zhang Juan Li Jin Ma Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea BMC Women's Health Obstructive sleep apnea Menopausal Epicardial fat thickness Apnea–hypopnea index Body mass index |
author_facet |
Yong Zhang Jian Wang Wen Shui Zhenxia Zhang Juan Li Jin Ma |
author_sort |
Yong Zhang |
title |
Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea |
title_short |
Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea |
title_full |
Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea |
title_fullStr |
Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea |
title_full_unstemmed |
Different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea |
title_sort |
different clinical parameters inform epicardial fat thickness in pre- and post-menopausal women with obstructive sleep apnea |
publisher |
BMC |
series |
BMC Women's Health |
issn |
1472-6874 |
publishDate |
2021-06-01 |
description |
Abstract Background Obstructive sleep apnea (OSA) is a sleep-related disorder with breathing difficulties. Previous studies revealed that epicardial fat thickness (EFT) correlates with OSA severity. Interestingly, female patients display a stronger EFT-OSA correlation than males. The purpose of this study is to investigate the relationship between EFT and different clinical characteristics in pre- and post-menopausal women diagnosed with OSA. Methods Patients diagnosed with OSA were divided into pre/early peri-menopausal (Group 1) and post/late peri-menopausal (Group 2) according to the menopause status. EFT was obtained from parasternal long-axis echocardiographic images. We also collected general clinical characteristics of patients involved in this study, and performed spearman correlation analysis to explore the correlations between EFT and the general clinical characteristics. We further applied Multiple stepwise linear regression analysis to explore the predictors for EFT in both groups. Results A total number of 23 and 59 patients were enrolled in Group 1 and Group 2 respectively. EFT in Group 2 was significantly higher than that of Group 1. In both groups, EFT was positively correlated with apnea–hypopnea index (AHI), percentage of total sleep time when blood oxygen saturation was less than 90% (T90), oxygen desaturation index (ODI) and glucose; while EFT was negatively correlated with mean and lowest SaO2 (oxygen saturation) levels. However, EFT was positively correlated with total cholesterol (TC) only in Group 1 and body mass index (BMI) only in Group2, respectively. Multiple stepwise linear regression analysis showed that AHI was independently associated with EFT in Group 1. However, both AHI and BMI were independent predictors of EFT in Group 2. Conclusion EFT was notably correlated with menopausal status in women with OSA. AHI was the independent predictor of EFT in women with OSA. BMI was the independent predictor of EFT in post/late peri-menopausal women with OSA. |
topic |
Obstructive sleep apnea Menopausal Epicardial fat thickness Apnea–hypopnea index Body mass index |
url |
https://doi.org/10.1186/s12905-021-01384-4 |
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