Lysosome trafficking is necessary for EGF-driven invasion and is regulated by p38 MAPK and Na+/H+ exchangers

Lysosome trafficking is necessary for EGF-driven invasion and is regulated by p38 MAPK and Na+/H+ exchangers

Abstract Background Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a majority of solid tumors. Basement membrane breakdown is one of the hal...

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Bibliographic Details
Main Authors: Samantha S. Dykes, Joshua J. Steffan, James A. Cardelli
Format: Article
Language:English
Published: BMC 2017-10-01
Series:BMC Cancer
Subjects:
Lysosome
Trafficking
EGF
p38
NHE
Signaling
Online Access:http://link.springer.com/article/10.1186/s12885-017-3660-3

Internet

http://link.springer.com/article/10.1186/s12885-017-3660-3

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