The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
SARS-CoV-2 nucleocapsid (N) protein is responsible for viral genome packaging. Here the authors employ single-molecule spectroscopy with all-atom simulations to provide the molecular details of N protein and show that it undergoes phase separation with RNA.
Bibliographic Details
| Main Authors: |
Jasmine Cubuk,
Jhullian J. Alston,
J. Jeremías Incicco,
Sukrit Singh,
Melissa D. Stuchell-Brereton,
Michael D. Ward,
Maxwell I. Zimmerman,
Neha Vithani,
Daniel Griffith,
Jason A. Wagoner,
Gregory R. Bowman,
Kathleen B. Hall,
Andrea Soranno,
Alex S. Holehouse |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-21953-3
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