H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer

H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer

Abstract Background H. pylori CagL-Y58/E59 increase gastric cancer risk by stronger binding with integrin to faciliate type IV secretory system (T4SS). H. pylori can secrete high temperature requirement A (HtrA) to mediate E-Cadherin cleavage for gastric epithelial junction disruption, so H. pylori...

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Bibliographic Details
Main Authors: Yi-Chun Yeh, Hsin-Yu Kuo, Wei-Lun Chang, Hsiao-Bai Yang, Cheng-Chan Lu, Hsiu-Chi Cheng, Ming-Shiang Wu, Bor-Shyang Sheu
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Biomedical Science
Subjects:
Gastric cancer
H. pylori
HtrA
CagL
Type IV secretory system
Online Access:http://link.springer.com/article/10.1186/s12929-019-0498-9

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