Porcine epidemic diarrhoea virus induces cell-cycle arrest through the DNA damage-signalling pathway

Porcine epidemic diarrhoea virus induces cell-cycle arrest through the DNA damage-signalling pathway

Porcine epidemic diarrhoea virus (PEDV) infection causes watery diarrhoea, vomiting, anorexia, and weight loss, especially among neonatal piglets, inflicting on them morbidity and mortality potentially reaching 90%–100%. Despite it being known that certain mammalian cell phases are arrested by PEDV,...

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Bibliographic Details
Main Authors: Luo Yi-Ran, Zhou Shu-Ting, Yang Liang, Liu Yuan-Ping, Jiang Sheng-Yao, Dawuli Yeliboli, Hou Yi-Xuan, Zhou Tian-Xing, Yang Zhi-Biao
Format: Article
Language:English
Published: Sciendo 2020-03-01
Series:Journal of Veterinary Research
Subjects:
porcine epidemic diarrhoea virus
cell cycle
virus proliferation
dna damage
signalling pathways
Online Access:https://doi.org/10.2478/jvetres-2020-0024
Description
Summary:Porcine epidemic diarrhoea virus (PEDV) infection causes watery diarrhoea, vomiting, anorexia, and weight loss, especially among neonatal piglets, inflicting on them morbidity and mortality potentially reaching 90%–100%. Despite it being known that certain mammalian cell phases are arrested by PEDV, the mechanisms have not been elucidated, and PEDV pathogenesis is poorly understood. This study determined the effect of an epidemic PEDV strain on cell cycle progression.
ISSN:2450-8608

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