Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma

Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma

The incidence of renal cell carcinoma is higher in males than in females due to the different androgen receptor signaling but the molecular mechanisms behind this gender bias are unclear. Here the authors show how androgen receptor expression influences the metastatic route through the regulation of...

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Main Authors: Qingbo Huang, Yin Sun, Xin Ma, Yu Gao, Xintao Li, Yuanjie Niu, Xu Zhang, Chawnshang Chang
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00701-6
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spelling doaj-dd59eae932f04abc982fd88aa1d85ae62021-05-11T07:09:27ZengNature Publishing GroupNature Communications2041-17232017-10-018111510.1038/s41467-017-00701-6Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinomaQingbo Huang0Yin Sun1Xin Ma2Yu Gao3Xintao Li4Yuanjie Niu5Xu Zhang6Chawnshang Chang7Department of Urology, Chinese PLA General HospitalGeorge Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical CenterDepartment of Urology, Chinese PLA General HospitalDepartment of Urology, Chinese PLA General HospitalDepartment of Urology, Chinese PLA General HospitalChawnshang Chang Sex Hormone Research Center, Tianjin Institute of Urology, Tianjin Medical UniversityDepartment of Urology, Chinese PLA General HospitalGeorge Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical CenterThe incidence of renal cell carcinoma is higher in males than in females due to the different androgen receptor signaling but the molecular mechanisms behind this gender bias are unclear. Here the authors show how androgen receptor expression influences the metastatic route through the regulation of miR-185 and VEGF isoforms.https://doi.org/10.1038/s41467-017-00701-6
collection DOAJ
language English
format Article
sources DOAJ
author Qingbo Huang
Yin Sun
Xin Ma
Yu Gao
Xintao Li
Yuanjie Niu
Xu Zhang
Chawnshang Chang
spellingShingle Qingbo Huang
Yin Sun
Xin Ma
Yu Gao
Xintao Li
Yuanjie Niu
Xu Zhang
Chawnshang Chang
Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
Nature Communications
author_facet Qingbo Huang
Yin Sun
Xin Ma
Yu Gao
Xintao Li
Yuanjie Niu
Xu Zhang
Chawnshang Chang
author_sort Qingbo Huang
title Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_short Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_full Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_fullStr Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_full_unstemmed Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
title_sort androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-10-01
description The incidence of renal cell carcinoma is higher in males than in females due to the different androgen receptor signaling but the molecular mechanisms behind this gender bias are unclear. Here the authors show how androgen receptor expression influences the metastatic route through the regulation of miR-185 and VEGF isoforms.
url https://doi.org/10.1038/s41467-017-00701-6
work_keys_str_mv AT qingbohuang androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
AT yinsun androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
AT xinma androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
AT yugao androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
AT xintaoli androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
AT yuanjieniu androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
AT xuzhang androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
AT chawnshangchang androgenreceptorincreaseshematogenousmetastasisyetdecreaseslymphaticmetastasisofrenalcellcarcinoma
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