Glucocorticoid Receptor α Mediates Roflumilast’s Ability to Restore Dexamethasone Sensitivity in COPD

Glucocorticoid Receptor α Mediates Roflumilast’s Ability to Restore Dexamethasone Sensitivity in COPD

Aravind T Reddy, 1, 2 Sowmya P Lakshmi, 1, 2 Asoka Banno, 1 Raju C Reddy 1, 2 1Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; 2Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 1...

Full description

Bibliographic Details
Main Authors:	Reddy AT, Lakshmi SP, Banno A, Reddy RC
Format:	Article
Language:	English
Published:	Dove Medical Press 2020-01-01
Series:	International Journal of COPD
Subjects:	nuclear hormone receptor glucocorticoid resistance phosphodiesterase-4 (pde4) inhibitor airway inflammation nf-κb camp response element binding protein (creb)
Online Access:	https://www.dovepress.com/glucocorticoid-receptor-alpha-mediates-roflumilastrsquos-ability-to-re-peer-reviewed-article-COPD

Similar Items

Phosphodiesterase 4 Inhibitor Roflumilast Protects Rat Hippocampal Neurons from Sevoflurane Induced Injury via Modulation of MEK/ERK Signaling Pathway
by: Sheng Peng, et al.
Published: (2018-03-01)

Dexamethasone Inhibits Synergistic Induction of PDE4B Expression by Roflumilast and Bacterium NTHi
by: Byung-Cheol Lee, et al.
Published: (2018-11-01)

Roflumilast: A Review of Chronic Obstructive Pulmonary Disease (COPD) Treatment
by: Ita Octafia, et al.
Published: (2021-01-01)

Dominant-Negative Attenuation of cAMP-Selective Phosphodiesterase PDE4D Action Affects Learning and Behavior
by: Graeme B. Bolger, et al.
Published: (2020-08-01)

Roflumilast: a review of its use in the treatment of COPD
by: Wedzicha JA, et al.
Published: (2016-01-01)

cAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in rats
by: Liu X, et al.
Published: (2016-01-01)

Genetic Association of Phosphodiesterases With Human Cognitive Performance
by: Mark E. Gurney
Published: (2019-02-01)

Pharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap
by: Zhang X, et al.
Published: (2018-08-01)

Phosphodiesterases as Crucial Regulators of Cardiomyocyte cAMP in Health and Disease
by: Perera, Ruwan K.
Published: (2014)

A Dose-Ranging Study of the Novel Inhaled Dual PDE 3 and 4 Inhibitor Ensifentrine in Patients with COPD Receiving Maintenance Tiotropium Therapy
by: Ferguson GT, et al.
Published: (2021-04-01)

Traumatic brain injury upregulates phosphodiesterase expression in the hippocampus
by: Nicole M Wilson, et al.
Published: (2016-02-01)

Phosphodiesterase-4 Inhibition in Psoriasis
by: Milakovic M, et al.
Published: (2021-03-01)

Emerging pharmaceutical therapies for COPD
by: Lakshmi SP, et al.
Published: (2017-07-01)

Role of Phosphodiesterase 7 (PDE7) in T Cell Activity. Effects of Selective PDE7 Inhibitors and Dual PDE4/7 Inhibitors on T Cell Functions
by: Marianna Szczypka
Published: (2020-08-01)

Crisaborole Ointment Improves Quality of Life of Patients with Mild to Moderate Atopic Dermatitis and Their Families
by: Eric L. Simpson, et al.
Published: (2018-10-01)

Phosphodiesterase 4B: Master Regulator of Brain Signaling
by: Amy J. Tibbo, et al.
Published: (2020-05-01)

Health status in patients with COPD treated with roflumilast: two large noninterventional real-life studies: DINO and DACOTA
by: Kardos P, et al.
Published: (2018-05-01)

Einfluss der Herzinsuffizienz auf Membranstrukturen und lokale cAMP-Dynamiken der SERCA2a-Mikrodomäne
by: Hofmann, Sandra
Published: (2016)

Behavioral neuroadaptation to alcohol : from glucocorticoids to histone acetylation
by: Daniel Beracochea, et al.
Published: (2016-10-01)

Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System
by: Maria Ercu, et al.
Published: (2018-02-01)

Differential expression and function of PDE8 and PDE4 in effector T cells: Implications for PDE8 as a drug target in inflammation.
by: Amanda G. Vang, et al.
Published: (2016-08-01)

Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases
by: Vincent Lagente, et al.
Published: (2005-03-01)

Mathematical Modelling of Nitric Oxide/Cyclic GMP/Cyclic AMP Signalling in Platelets
by: Rune Kleppe, et al.
Published: (2018-02-01)

BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-κB and Activating PKA/CREB
by: Chuwen Li, et al.
Published: (2018-06-01)

Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects
by: Deschesnes Francine, et al.
Published: (2011-10-01)

Glucocorticoids Regulate the Activation of Neutrophils and Inhibit the Formation of Pulmonary Embolism
by: Zhefeng Meng, et al.
Published: (2020-12-01)

A Way to Increase the Bioaccesibility and Photostability of Roflumilast, a COPD Treatment, by Cyclodextrin Monomers
by: Adrián Matencio, et al.
Published: (2019-05-01)

Functions of PDE3 Isoforms in Cardiac Muscle
by: Matthew Movsesian, et al.
Published: (2018-02-01)

The Role of PDE8 in T Cell Recruitment and Function in Inflammation
by: Paul M. Epstein, et al.
Published: (2021-04-01)

Effects of Roflumilast, Selective PDE4 Inhibitor, on Airway Reactivity in Ovalbumin-Sensitized Guinea Pigs
by: Tharmalingam Nirmathan, et al.
Published: (2015-05-01)

Phosphodiesterase 3 mediates cross-talk between the protein kinase- and cGMP- dependent pathways and cyclic AMP metabolism
by: Edyta Makuch, et al.
Published: (2012-07-01)

Airway Ciliary Beating Affected by the <i>Pcp4</i> Dose-Dependent [Ca<sup>2+</sup>]<sub>i</sub> Increase in Down Syndrome Mice, Ts1Rhr
by: Haruka Kogiso, et al.
Published: (2020-03-01)

Seihai-to (TJ-90)-Induced Activation of Airway Ciliary Beatings of Mice: Ca2+ Modulation of cAMP-Stimulated Ciliary Beatings via PDE1
by: Haruka Kogiso, et al.
Published: (2018-02-01)

Effect of cAMP signaling on expression of glucocorticoid receptor, Bim and Bad in glucocorticoid-sensitive and resistant leukemic and multiple myeloma cells
by: Hongli eDong, et al.
Published: (2015-10-01)

Enhancement of skin barrier and hydration-related molecules by protopanaxatriol in human keratinocytes
by: Jeong-Oog Lee, et al.
Published: (2021-03-01)

Risk factors for the discontinuation of roflumilast in patients with chronic obstructive pulmonary disease
by: Kim KH, et al.
Published: (2017-12-01)

Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D
by: Meiqin Huang, et al.
Published: (2021-05-01)

Modulation of Compartmentalised Cyclic Nucleotide Signalling via Local Inhibition of Phosphodiesterase Activity
by: Marcella Brescia, et al.
Published: (2016-10-01)

Segregation of Incomplete Achromatopsia and Alopecia Due to PDE6H and LPAR6 Variants in a Consanguineous Family from Pakistan
by: Christeen Ramane J. Pedurupillay, et al.
Published: (2016-07-01)

In Search of Monocot Phosphodiesterases: Identification of a Calmodulin Stimulated Phosphodiesterase from <i>Brachypodium distachyon</i>
by: Mateusz Kwiatkowski, et al.
Published: (2021-09-01)