Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis

Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis

Abstract Human inflammatory or neurodegenerative diseases, such as progressive multiple sclerosis (MS), occur on a background of age-related microglia activation and iron accumulation as well as pre-existing neurodegeneration. Most experimental models for CNS diseases, however, are induced in rodent...

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Bibliographic Details
Main Authors: Isabella Wimmer, Cornelia Scharler, Tobias Zrzavy, Taro Kadowaki, Verena Mödlagl, Kim Rojc, Anna R. Tröscher, Maja Kitic, Shuichi Ueda, Monika Bradl, Hans Lassmann
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Acta Neuropathologica Communications
Subjects:
Progressive multiple sclerosis
Experimental autoimmune encephalitis
Neurodegeneration
Microglia
Zitter rat
Online Access:http://link.springer.com/article/10.1186/s40478-019-0667-9

Internet

http://link.springer.com/article/10.1186/s40478-019-0667-9

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