Suppressing Cdk5 Activity by Luteolin Inhibits MPP<sup>+</sup>-Induced Apoptotic of Neuroblastoma through Erk/Drp1 and Fak/Akt/GSK3β Pathways

Suppressing Cdk5 Activity by Luteolin Inhibits MPP<sup>+</sup>-Induced Apoptotic of Neuroblastoma through Erk/Drp1 and Fak/Akt/GSK3β Pathways

Parkinson’s disease (PD) is characterized by the progressive degeneration of dopaminergic neurons. The cause of PD is still unclear. Oxidative stress and mitochondrial dysfunction have been linked to the development of PD. Luteolin, a non-toxic flavonoid, has become interested in an alternative medi...

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Bibliographic Details
Main Authors: Ratchaneekorn Reudhabibadh, Thunwa Binlateh, Pennapa Chonpathompikunlert, Nongyao Nonpanya, Peerada Prommeenate, Pithi Chanvorachote, Pilaiwanwadee Hutamekalin
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
1-methyl-4-phenylpyridinium ion
apoptosis
Cdk5
luteolin
oxidative stress
Parkinson’s disease
Online Access:https://www.mdpi.com/1420-3049/26/5/1307

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