Fine-Tuning the Activation Mode of an 1,3-Indandione-Based Ruthenium(II)-Cymene Half-Sandwich Complex by Variation of Its Leaving Group

Fine-Tuning the Activation Mode of an 1,3-Indandione-Based Ruthenium(II)-Cymene Half-Sandwich Complex by Variation of Its Leaving Group

Fine-tuning of the properties of a recently reported 1,3-indandione-based organoruthenium complex is attempted to optimize the stability under physiological conditions. Previous work has shown its capacity of inhibiting topoisomerase IIα; however, fast aquation leads to undesired reactions...

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Bibliographic Details
Main Authors:	Stephan Mokesch, Daniela Schwarz, Michaela Hejl, Matthias H. M. Klose, Alexander Roller, Michael A. Jakupec, Wolfgang Kandioller, Bernhard K. Keppler
Format:	Article
Language:	English
Published:	MDPI AG 2019-06-01
Series:	Molecules
Subjects:	half-sandwich complexes ruthenium(II)–arene complexes leaving group variation anticancer drugs
Online Access:	https://www.mdpi.com/1420-3049/24/13/2373

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