Neurodegenerative phosphoprotein signaling landscape in models of SCA3

Neurodegenerative phosphoprotein signaling landscape in models of SCA3

Abstract Spinocerebellar ataxia type 3 (SCA3) is a rare neurodegenerative disorder resulting from an aberrant expansion of a polyglutamine stretch in the ataxin-3 protein and subsequent neuronal death. The underlying intracellular signaling pathways are currently unknown. We applied the Reverse-phas...

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Bibliographic Details
Main Authors: Anna S. Sowa, Taissia G. Popova, Tina Harmuth, Jonasz J. Weber, Priscila Pereira Sena, Jana Schmidt, Jeannette Hübener-Schmid, Thorsten Schmidt
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Molecular Brain
Subjects:
Spinocerebellar ataxia type 3 (SCA3)
Machado-Joseph disease (MJD)
Ataxin-3 (ATXN3)
RPMA
Neurodegeneration
pERK
Online Access:https://doi.org/10.1186/s13041-020-00723-0

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