Human Serum Albumin Binds Streptolysin O (SLO) Toxin Produced by Group A Streptococcus and Inhibits Its Cytotoxic and Hemolytic Effects

Human Serum Albumin Binds Streptolysin O (SLO) Toxin Produced by Group A Streptococcus and Inhibits Its Cytotoxic and Hemolytic Effects

The pathogenicity of group A Streptococcus (GAS) is mediated by direct bacterial invasivity and toxin-associated damage. Among the extracellular products, the exotoxin streptolysin O (SLO) is produced by almost all GAS strains. SLO is a pore forming toxin (PFT) hemolitically active and extremely tox...

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Bibliographic Details
Main Authors: Gian Marco Vita, Giovanna De Simone, Loris Leboffe, Francesca Montagnani, Davide Mariotti, Stefano Di Bella, Roberto Luzzati, Andrea Gori, Paolo Ascenzi, Alessandra di Masi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
human serum albumin
red blood cells
streptolysin O
Streptococcus pyogenes
toxin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.507092/full

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