Genomic characterization of the human mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>): 5' cloning and preliminary analysis of the multiple gene promoters

• Main Authors: Ye Hui, Liu Xiqiang, Yu Jinsheng, Zhou Xiaofeng
• Format: Article
• Language: English
• Published: BMC 2009-06-01
• Series: BMC Research Notes
• Online Access: http://www.biomedcentral.com/1756-0500/2/109

<p>Abstract</p> <p>Background</p> <p>Mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>) has been recently identified as a candidate tumor suppressor gene which resides in a genomic region (8p22) that shows frequent loss of heterozygosity (LOH) in several tumor types. It has been suggested that multiple gene promoters and alternative splicing lead to the expression of 5 known <it>MTUS1 </it>transcript variants.</p> <p>Findings</p> <p>Here, we characterized the 5' untranslated regions of the different transcript variants. We also cloned and functionally tested the alternatively utilized gene promoters that contribute to the production of different <it>MTUS1 </it>transcript variants.</p> <p>Conclusion</p> <p>Our results confirmed the early hypothesis that the transcript variants of <it>MTUS1 </it>gene are driven by multiple gene promoters.</p>