Genomic characterization of the human mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>): 5' cloning and preliminary analysis of the multiple gene promoters
<p>Abstract</p> <p>Background</p> <p>Mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>) has been recently identified as a candidate tumor suppressor gene which resides in a genomic region (8p22) that shows frequent loss of heterozygosity (LOH) in several...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-06-01
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| Series: | BMC Research Notes |
| Online Access: | http://www.biomedcentral.com/1756-0500/2/109 |
| Summary: | <p>Abstract</p> <p>Background</p> <p>Mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>) has been recently identified as a candidate tumor suppressor gene which resides in a genomic region (8p22) that shows frequent loss of heterozygosity (LOH) in several tumor types. It has been suggested that multiple gene promoters and alternative splicing lead to the expression of 5 known <it>MTUS1 </it>transcript variants.</p> <p>Findings</p> <p>Here, we characterized the 5' untranslated regions of the different transcript variants. We also cloned and functionally tested the alternatively utilized gene promoters that contribute to the production of different <it>MTUS1 </it>transcript variants.</p> <p>Conclusion</p> <p>Our results confirmed the early hypothesis that the transcript variants of <it>MTUS1 </it>gene are driven by multiple gene promoters.</p> |
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| ISSN: | 1756-0500 |