Efficacy of HDAC Inhibitors Belinostat and Panobinostat against Cisplatin-Sensitive and Cisplatin-Resistant Testicular Germ Cell Tumors

Efficacy of HDAC Inhibitors Belinostat and Panobinostat against Cisplatin-Sensitive and Cisplatin-Resistant Testicular Germ Cell Tumors

Novel treatment options are needed for testicular germ cell tumor (TGCT) patients, particularly important for those showing or developing cisplatin resistance, the major cause of cancer-related deaths. As TGCTs pathobiology is highly related to epigenetic (de)regulation, epidrugs are potentially eff...

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Bibliographic Details
Main Authors: João Lobo, Catarina Guimarães-Teixeira, Daniela Barros-Silva, Vera Miranda-Gonçalves, Vânia Camilo, Rita Guimarães, Mariana Cantante, Isaac Braga, Joaquina Maurício, Christoph Oing, Friedemann Honecker, Daniel Nettersheim, Leendert HJ Looijenga, Rui Henrique, Carmen Jerónimo
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
testicular germ cell tumors
cisplatin resistance
targeted therapies
epidrugs
HDAC inhibitors
belinostat
Online Access:https://www.mdpi.com/2072-6694/12/10/2903

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