A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression

In melanoma, reduced ADAR1 impairs A-to-I microRNA editing. Here, the authors show that miR-378a-3p undergoes this editing in non-metastatic cells and the edited form of miR-378a-3p binds to the PARVA oncogene, inhibiting its expression and preventing melanoma progression and metastasis.

Bibliographic Details
Main Authors: Guermarie Velazquez-Torres, Einav Shoshan, Cristina Ivan, Li Huang, Enrique Fuentes-Mattei, Harrison Paret, Sun Jin Kim, Cristian Rodriguez-Aguayo, Victoria Xie, Denise Brooks, Steven J. M. Jones, A. Gordon Robertson, George Calin, Gabriel Lopez-Berenstein, Anil Sood, Menashe Bar-Eli
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-02851-7
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spelling doaj-dd20c2509c0c46dbbe02e75f436eee1a2021-05-11T09:52:38ZengNature Publishing GroupNature Communications2041-17232018-01-01911710.1038/s41467-018-02851-7A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expressionGuermarie Velazquez-Torres0Einav Shoshan1Cristina Ivan2Li Huang3Enrique Fuentes-Mattei4Harrison Paret5Sun Jin Kim6Cristian Rodriguez-Aguayo7Victoria Xie8Denise Brooks9Steven J. M. Jones10A. Gordon Robertson11George Calin12Gabriel Lopez-Berenstein13Anil Sood14Menashe Bar-Eli15Department of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer CenterDepartment of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer CenterDepartment of Gynecologic Oncology, Unit 1362, The University of Texas MD Anderson Cancer CenterDepartment of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Therapeutics, Unit 1950, The University of Texas MD Anderson Cancer CenterDepartment of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer CenterDepartment of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Therapeutics, Unit 1950, The University of Texas MD Anderson Cancer CenterDepartment of Neurosurgery, The University of Texas MD Anderson Cancer CenterCanada’s Michael Smith Cancer AgencyCanada’s Michael Smith Cancer AgencyCanada’s Michael Smith Cancer AgencyDepartment of Experimental Therapeutics, Unit 1950, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Therapeutics, Unit 1950, The University of Texas MD Anderson Cancer CenterDepartment of Gynecologic Oncology, Unit 1362, The University of Texas MD Anderson Cancer CenterDepartment of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer CenterIn melanoma, reduced ADAR1 impairs A-to-I microRNA editing. Here, the authors show that miR-378a-3p undergoes this editing in non-metastatic cells and the edited form of miR-378a-3p binds to the PARVA oncogene, inhibiting its expression and preventing melanoma progression and metastasis.https://doi.org/10.1038/s41467-018-02851-7
collection DOAJ
language English
format Article
sources DOAJ
author Guermarie Velazquez-Torres
Einav Shoshan
Cristina Ivan
Li Huang
Enrique Fuentes-Mattei
Harrison Paret
Sun Jin Kim
Cristian Rodriguez-Aguayo
Victoria Xie
Denise Brooks
Steven J. M. Jones
A. Gordon Robertson
George Calin
Gabriel Lopez-Berenstein
Anil Sood
Menashe Bar-Eli
spellingShingle Guermarie Velazquez-Torres
Einav Shoshan
Cristina Ivan
Li Huang
Enrique Fuentes-Mattei
Harrison Paret
Sun Jin Kim
Cristian Rodriguez-Aguayo
Victoria Xie
Denise Brooks
Steven J. M. Jones
A. Gordon Robertson
George Calin
Gabriel Lopez-Berenstein
Anil Sood
Menashe Bar-Eli
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
Nature Communications
author_facet Guermarie Velazquez-Torres
Einav Shoshan
Cristina Ivan
Li Huang
Enrique Fuentes-Mattei
Harrison Paret
Sun Jin Kim
Cristian Rodriguez-Aguayo
Victoria Xie
Denise Brooks
Steven J. M. Jones
A. Gordon Robertson
George Calin
Gabriel Lopez-Berenstein
Anil Sood
Menashe Bar-Eli
author_sort Guermarie Velazquez-Torres
title A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
title_short A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
title_full A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
title_fullStr A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
title_full_unstemmed A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
title_sort a-to-i mir-378a-3p editing can prevent melanoma progression via regulation of parva expression
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-01-01
description In melanoma, reduced ADAR1 impairs A-to-I microRNA editing. Here, the authors show that miR-378a-3p undergoes this editing in non-metastatic cells and the edited form of miR-378a-3p binds to the PARVA oncogene, inhibiting its expression and preventing melanoma progression and metastasis.
url https://doi.org/10.1038/s41467-018-02851-7
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