A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
In melanoma, reduced ADAR1 impairs A-to-I microRNA editing. Here, the authors show that miR-378a-3p undergoes this editing in non-metastatic cells and the edited form of miR-378a-3p binds to the PARVA oncogene, inhibiting its expression and preventing melanoma progression and metastasis.
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2018-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-02851-7 |
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doaj-dd20c2509c0c46dbbe02e75f436eee1a2021-05-11T09:52:38ZengNature Publishing GroupNature Communications2041-17232018-01-01911710.1038/s41467-018-02851-7A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expressionGuermarie Velazquez-Torres0Einav Shoshan1Cristina Ivan2Li Huang3Enrique Fuentes-Mattei4Harrison Paret5Sun Jin Kim6Cristian Rodriguez-Aguayo7Victoria Xie8Denise Brooks9Steven J. M. Jones10A. Gordon Robertson11George Calin12Gabriel Lopez-Berenstein13Anil Sood14Menashe Bar-Eli15Department of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer CenterDepartment of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer CenterDepartment of Gynecologic Oncology, Unit 1362, The University of Texas MD Anderson Cancer CenterDepartment of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Therapeutics, Unit 1950, The University of Texas MD Anderson Cancer CenterDepartment of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer CenterDepartment of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Therapeutics, Unit 1950, The University of Texas MD Anderson Cancer CenterDepartment of Neurosurgery, The University of Texas MD Anderson Cancer CenterCanada’s Michael Smith Cancer AgencyCanada’s Michael Smith Cancer AgencyCanada’s Michael Smith Cancer AgencyDepartment of Experimental Therapeutics, Unit 1950, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Therapeutics, Unit 1950, The University of Texas MD Anderson Cancer CenterDepartment of Gynecologic Oncology, Unit 1362, The University of Texas MD Anderson Cancer CenterDepartment of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer CenterIn melanoma, reduced ADAR1 impairs A-to-I microRNA editing. Here, the authors show that miR-378a-3p undergoes this editing in non-metastatic cells and the edited form of miR-378a-3p binds to the PARVA oncogene, inhibiting its expression and preventing melanoma progression and metastasis.https://doi.org/10.1038/s41467-018-02851-7 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guermarie Velazquez-Torres Einav Shoshan Cristina Ivan Li Huang Enrique Fuentes-Mattei Harrison Paret Sun Jin Kim Cristian Rodriguez-Aguayo Victoria Xie Denise Brooks Steven J. M. Jones A. Gordon Robertson George Calin Gabriel Lopez-Berenstein Anil Sood Menashe Bar-Eli |
spellingShingle |
Guermarie Velazquez-Torres Einav Shoshan Cristina Ivan Li Huang Enrique Fuentes-Mattei Harrison Paret Sun Jin Kim Cristian Rodriguez-Aguayo Victoria Xie Denise Brooks Steven J. M. Jones A. Gordon Robertson George Calin Gabriel Lopez-Berenstein Anil Sood Menashe Bar-Eli A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression Nature Communications |
author_facet |
Guermarie Velazquez-Torres Einav Shoshan Cristina Ivan Li Huang Enrique Fuentes-Mattei Harrison Paret Sun Jin Kim Cristian Rodriguez-Aguayo Victoria Xie Denise Brooks Steven J. M. Jones A. Gordon Robertson George Calin Gabriel Lopez-Berenstein Anil Sood Menashe Bar-Eli |
author_sort |
Guermarie Velazquez-Torres |
title |
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression |
title_short |
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression |
title_full |
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression |
title_fullStr |
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression |
title_full_unstemmed |
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression |
title_sort |
a-to-i mir-378a-3p editing can prevent melanoma progression via regulation of parva expression |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-01-01 |
description |
In melanoma, reduced ADAR1 impairs A-to-I microRNA editing. Here, the authors show that miR-378a-3p undergoes this editing in non-metastatic cells and the edited form of miR-378a-3p binds to the PARVA oncogene, inhibiting its expression and preventing melanoma progression and metastasis. |
url |
https://doi.org/10.1038/s41467-018-02851-7 |
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