Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin

Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis...

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Main Authors:	Yinka K. Davies, Cynthia J. Tsay, Dario V. Caccamo, Kathleen M. Cox, Ricardo O. Castillo, Kenneth L. Cox
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	Case Reports in Transplantation
Online Access:	http://dx.doi.org/10.1155/2013/314292

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spelling	doaj-dd1cf36ca4bb49db8357ff8da8a2466b2020-11-24T23:15:33ZengHindawi LimitedCase Reports in Transplantation2090-69432090-69512013-01-01201310.1155/2013/314292314292Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral VancomycinYinka K. Davies0Cynthia J. Tsay1Dario V. Caccamo2Kathleen M. Cox3Ricardo O. Castillo4Kenneth L. Cox5Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA 95762, USAYale University, New Haven, CT 06510, USADepartment of Pathology, Sutter Medical Center, Sacramento, CA 95816, USADivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA 95762, USADivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA 95762, USADivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA 95762, USAPrimary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis and cirrhosis of the liver. Due to limited understanding of the etiology and mechanism of PSC, the only existing treatment option is orthotopic liver transplantation (OLT); however, recurrence of PSC, after OLT is estimated to be between 5% and 35%. We discuss the successful treatment of a pediatric patient, with recurrent PSC, after OLT with oral Vancomycin.http://dx.doi.org/10.1155/2013/314292
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yinka K. Davies Cynthia J. Tsay Dario V. Caccamo Kathleen M. Cox Ricardo O. Castillo Kenneth L. Cox
spellingShingle	Yinka K. Davies Cynthia J. Tsay Dario V. Caccamo Kathleen M. Cox Ricardo O. Castillo Kenneth L. Cox Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin Case Reports in Transplantation
author_facet	Yinka K. Davies Cynthia J. Tsay Dario V. Caccamo Kathleen M. Cox Ricardo O. Castillo Kenneth L. Cox
author_sort	Yinka K. Davies
title	Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin
title_short	Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin
title_full	Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin
title_fullStr	Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin
title_full_unstemmed	Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin
title_sort	successful treatment of recurrent primary sclerosing cholangitis after orthotopic liver transplantation with oral vancomycin
publisher	Hindawi Limited
series	Case Reports in Transplantation
issn	2090-6943 2090-6951
publishDate	2013-01-01
description	Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis and cirrhosis of the liver. Due to limited understanding of the etiology and mechanism of PSC, the only existing treatment option is orthotopic liver transplantation (OLT); however, recurrence of PSC, after OLT is estimated to be between 5% and 35%. We discuss the successful treatment of a pediatric patient, with recurrent PSC, after OLT with oral Vancomycin.
url	http://dx.doi.org/10.1155/2013/314292
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Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin

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