Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways

Receptor tyrosine kinases are often activated in malignant gliomas. Here, the authors develop a dual functionalized brain targeting nano-inhibitor to simultaneously target EGFR and MET pathways, and show this can overcome temozolomide resistance in glioma.

Bibliographic Details
Main Authors:	Xiangqi Meng, Yu Zhao, Bo Han, Caijun Zha, Yangong Zhang, Ziwei Li, Pengfei Wu, Tengfei Qi, Chuanlu Jiang, Yang Liu, Jinquan Cai
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-14036-x

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spelling	doaj-dd170487e7734f4a8de5b105c70b72722021-05-11T09:04:59ZengNature Publishing GroupNature Communications2041-17232020-01-0111111510.1038/s41467-019-14036-xDual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathwaysXiangqi Meng0Yu Zhao1Bo Han2Caijun Zha3Yangong Zhang4Ziwei Li5Pengfei Wu6Tengfei Qi7Chuanlu Jiang8Yang Liu9Jinquan Cai10Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical SciencesState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai UniversityDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical SciencesDepartment of Laboratory Diagnosis, The Second Affiliated Hospital of Harbin Medical UniversityDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical SciencesDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical SciencesDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical SciencesDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical SciencesDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical SciencesState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai UniversityDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical SciencesReceptor tyrosine kinases are often activated in malignant gliomas. Here, the authors develop a dual functionalized brain targeting nano-inhibitor to simultaneously target EGFR and MET pathways, and show this can overcome temozolomide resistance in glioma.https://doi.org/10.1038/s41467-019-14036-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xiangqi Meng Yu Zhao Bo Han Caijun Zha Yangong Zhang Ziwei Li Pengfei Wu Tengfei Qi Chuanlu Jiang Yang Liu Jinquan Cai
spellingShingle	Xiangqi Meng Yu Zhao Bo Han Caijun Zha Yangong Zhang Ziwei Li Pengfei Wu Tengfei Qi Chuanlu Jiang Yang Liu Jinquan Cai Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways Nature Communications
author_facet	Xiangqi Meng Yu Zhao Bo Han Caijun Zha Yangong Zhang Ziwei Li Pengfei Wu Tengfei Qi Chuanlu Jiang Yang Liu Jinquan Cai
author_sort	Xiangqi Meng
title	Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
title_short	Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
title_full	Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
title_fullStr	Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
title_full_unstemmed	Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
title_sort	dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating egfr and met signaling pathways
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	Receptor tyrosine kinases are often activated in malignant gliomas. Here, the authors develop a dual functionalized brain targeting nano-inhibitor to simultaneously target EGFR and MET pathways, and show this can overcome temozolomide resistance in glioma.
url	https://doi.org/10.1038/s41467-019-14036-x
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Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways

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