Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
Receptor tyrosine kinases are often activated in malignant gliomas. Here, the authors develop a dual functionalized brain targeting nano-inhibitor to simultaneously target EGFR and MET pathways, and show this can overcome temozolomide resistance in glioma.
Bibliographic Details
| Main Authors: |
Xiangqi Meng,
Yu Zhao,
Bo Han,
Caijun Zha,
Yangong Zhang,
Ziwei Li,
Pengfei Wu,
Tengfei Qi,
Chuanlu Jiang,
Yang Liu,
Jinquan Cai |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-14036-x
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