Immune Circuits to Shape Natural Killer Cells in Cancer
Natural killer (NK) cells are innate lymphoid cells playing an important role in anti-cancer immunity. NK cells are efficient in controlling the spreading of metastasis but are not very powerful in fighting against primary tumors. The NK cell capability to infiltrate and persist in the tumor microen...
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MDPI AG
2021-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/13/3225 |
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doaj-dd129cfbeb074ce59401b9949abd37782021-07-15T15:31:39ZengMDPI AGCancers2072-66942021-06-01133225322510.3390/cancers13133225Immune Circuits to Shape Natural Killer Cells in CancerIrene Mattiola0Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, GermanyNatural killer (NK) cells are innate lymphoid cells playing an important role in anti-cancer immunity. NK cells are efficient in controlling the spreading of metastasis but are not very powerful in fighting against primary tumors. The NK cell capability to infiltrate and persist in the tumor microenvironment and to exert their antitumoral functions is often limited by tumor escape mechanisms. These tumor-mediated strategies not only induce NK cell tolerance but also interfere with the NK cell-dependent immune networking. This review will provide an overview of the tumor escape mechanisms impacting NK cells, identify the immune circuits regulating the NK cell-dependent antitumor immunity and revise the emerging therapeutic approaches to unleash NK cells in cancer.https://www.mdpi.com/2072-6694/13/13/3225NK cellstumor microenvironmentcancer |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Irene Mattiola |
| spellingShingle |
Irene Mattiola Immune Circuits to Shape Natural Killer Cells in Cancer Cancers NK cells tumor microenvironment cancer |
| author_facet |
Irene Mattiola |
| author_sort |
Irene Mattiola |
| title |
Immune Circuits to Shape Natural Killer Cells in Cancer |
| title_short |
Immune Circuits to Shape Natural Killer Cells in Cancer |
| title_full |
Immune Circuits to Shape Natural Killer Cells in Cancer |
| title_fullStr |
Immune Circuits to Shape Natural Killer Cells in Cancer |
| title_full_unstemmed |
Immune Circuits to Shape Natural Killer Cells in Cancer |
| title_sort |
immune circuits to shape natural killer cells in cancer |
| publisher |
MDPI AG |
| series |
Cancers |
| issn |
2072-6694 |
| publishDate |
2021-06-01 |
| description |
Natural killer (NK) cells are innate lymphoid cells playing an important role in anti-cancer immunity. NK cells are efficient in controlling the spreading of metastasis but are not very powerful in fighting against primary tumors. The NK cell capability to infiltrate and persist in the tumor microenvironment and to exert their antitumoral functions is often limited by tumor escape mechanisms. These tumor-mediated strategies not only induce NK cell tolerance but also interfere with the NK cell-dependent immune networking. This review will provide an overview of the tumor escape mechanisms impacting NK cells, identify the immune circuits regulating the NK cell-dependent antitumor immunity and revise the emerging therapeutic approaches to unleash NK cells in cancer. |
| topic |
NK cells tumor microenvironment cancer |
| url |
https://www.mdpi.com/2072-6694/13/13/3225 |
| work_keys_str_mv |
AT irenemattiola immunecircuitstoshapenaturalkillercellsincancer |
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1721299967040028672 |