Preovulatory exposure to a protein-restricted diet disrupts amino acid kinetics and alters mitochondrial structure and function in the rat oocyte and is partially rescued by folic acid

Preovulatory exposure to a protein-restricted diet disrupts amino acid kinetics and alters mitochondrial structure and function in the rat oocyte and is partially rescued by folic acid

Abstract Background Detrimental exposures during pregnancy have been implicated in programming offspring to develop permanent changes in physiology and metabolism, increasing the risk for developing diseases in adulthood such as hypertension, diabetes, heart disease and obesity. This study investiga...

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Bibliographic Details
Main Authors: Amy K. Schutt, Chellakkan S. Blesson, Jean W. Hsu, Cecilia T. Valdes, William E. Gibbons, Farook Jahoor, Chandra Yallampalli
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Reproductive Biology and Endocrinology
Subjects:
Oocyte
Developmental programming
Amino acid
Metabolism
Protein restriction
Mitochondria
Online Access:http://link.springer.com/article/10.1186/s12958-019-0458-y

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