mTOR inhibitors in cancer therapy [version 1; referees: 3 approved]

mTOR inhibitors in cancer therapy [version 1; referees: 3 approved]

The mammalian target of rapamycin, mTOR, plays key roles in cell growth and proliferation, acting at the catalytic subunit of two protein kinase complexes: mTOR complexes 1 and 2 (mTORC1/2). mTORC1 signaling is switched on by several oncogenic signaling pathways and is accordingly hyperactive in the...

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Bibliographic Details
Main Authors: Jianling Xie, Xuemin Wang, Christopher G. Proud
Format: Article
Language:English
Published: F1000 Research Ltd 2016-08-01
Series:F1000Research
Subjects:
Cancer Therapeutics
Cell Growth & Division
Cell Signaling
Control of Gene Expression
Drug Discovery & Design
Medical Genetics
Membranes & Sorting
Pharmacokinetics & Drug Delivery
Online Access:http://f1000research.com/articles/5-2078/v1

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