Carbapenemase Producing Gram-Negative Bacteria in Tunisia: History of Thirteen Years of Challenge

• Main Authors: Dziri O, Dziri R, Ali El Salabi A, Chouchani C
• Format: Article
• Language: English
• Published: Dove Medical Press 2020-11-01
• Series: Infection and Drug Resistance
• Subjects: gram-negative bacteria; carbapenem resistance; carbapenemases; mobile genetic elements; tunisia.
• Online Access: https://www.dovepress.com/carbapenemase-producing-gram-negative-bacteria-in-tunisia-history-of-t-peer-reviewed-article-IDR
• ISSN: 1178-6973

Olfa Dziri,1,2 Raoudha Dziri,1 Allaaeddin Ali El Salabi,3,4 Chedly Chouchani1,2 1Laboratory of Microorganisms and Active Biomolecules, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia; 2Laboratory of Research in Sciences and Technology of Environment, High Institute of Science and Technology of Environment, University of Carthage, Hammam-Lif, Tunisia; 3Department of Environmental Health, Faculty of Public Health, University of Benghazi, Benghazi, Libya; 4Infection Control and Patient Safety Office, New Marwa Hospital, Benghazi, LibyaCorrespondence: Chedly ChouchaniISSTE de Borj-Cedria, Université de Carthage, Hammam-Lif BP-1003, 2050, TunisiaTel [phone]Fax [phone]Email [e-mail]: The wide spread of multidrug-resistant bacteria, particularly carbapenem-resistant Gram-negative bacteria (CR-GNB), constitutes a major public health threat worldwide, owing to the limited therapeutic options. This review will describe and uncover the Tunisian experience in the challenge against carbapenem resistance. Indeed, we illuminate on the dissemination of CR-GNB in different hospitals, animals, and other natural environments in this country. We resumed the different carbapenemase variants detected from various bacterial species and mapped their regional distribution, basing on Tunisian published data during a period extended from 2006, the date of its first description in Tunisia, to February 2019. We also resumed the different mobile genetic elements implicated in their dissemination. This review shows that the majority of the research reports focused in the north and the coastal cities in spite of the fact that KPC and IMP carbapenemases were uncommonly detected in our country. However, VIM, NDM-1, and OXA-48 enzymes were usually reported with the predominance of OXA-48 among Enterobacteriaceae. Furthermore, OXA-23, OXA-51, and OXA-58 carbapenemases constituted the main mechanism conferring carbapenem resistance among Acinetobacter baumannii in Tunisia. Collaborative efforts and raising awareness of the threat of antibiotic resistance are required in order to minimize the spread of multidrug-resistant bacteria.Keywords: Gram-negative bacteria, carbapenem resistance, carbapenemases, mobile genetic elements, Tunisia