DDX5 potentiates HIV-1 transcription as a co-factor of Tat

DDX5 potentiates HIV-1 transcription as a co-factor of Tat

Abstract Background HIV-1 does not encode a helicase and hijacks those of the cell for efficient replication. We and others previously showed that the DEAD box helicase, DDX5, is an essential HIV dependency factor. DDX5 was recently shown to be associated with the 7SK snRNP. Cellular positive transc...

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Bibliographic Details
Main Authors: Nyaradzai Sithole, Claire A. Williams, Truus E. M. Abbink, Andrew M. L. Lever
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Retrovirology
Subjects:
HIV-1
Tat
Transcription
P-TEFb
DEAD Box helicases
DDX5
Online Access:http://link.springer.com/article/10.1186/s12977-020-00514-4

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http://link.springer.com/article/10.1186/s12977-020-00514-4

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