Choroidal change in acute anterior uveitis associated with human leukocyte antigen-B27.

To evaluate choroidal changes in eyes with acute anterior uveitis associated with human leukocyte antigen (HLA)-B27.In 44 patients with first-onset, unilateral, acute-onset (<1 week) anterior uveitis for which diagnostic work-ups revealed positivity only for HLA-B27, wide-field three-dimensional...

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Main Authors: Seong Joon Ahn, Ji Hong Kim, Byung Ro Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5489203?pdf=render
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spelling doaj-dcf8227cf35241479f30462f8992d8732020-11-25T01:20:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e018010910.1371/journal.pone.0180109Choroidal change in acute anterior uveitis associated with human leukocyte antigen-B27.Seong Joon AhnJi Hong KimByung Ro LeeTo evaluate choroidal changes in eyes with acute anterior uveitis associated with human leukocyte antigen (HLA)-B27.In 44 patients with first-onset, unilateral, acute-onset (<1 week) anterior uveitis for which diagnostic work-ups revealed positivity only for HLA-B27, wide-field three-dimensional volumetric raster scan using swept-source optical coherence tomography was performed for both eyes. Choroidal thickness was measured by automated segmentation and thickness mapping and compared between eyes with uveitis and the fellow eyes at baseline. Choroidal thickness was compared before and after topical and/or systemic corticosteroid therapy. Relative choroidal thickening was defined as the choroidal thickness of the uveitic eye minus that of the corresponding eye and correlated with the degree of intraocular inflammation.Compared to the fellow eyes, eyes with acute anterior uveitis showed significant choroidal thickening on the subfoveal and parafoveal areas at baseline (all P <0.05). En face choroidal imaging showed dilation of large choroidal vessels on the macula. Relative choroidal thickening significantly correlated with the degree of anterior chamber inflammation at baseline (correlation coefficient = 0.341, P = 0.023). After treating inflammation, the choroid on the macula thinned significantly (from 262.1 ± 66.5 to 239.5 ± 61.0 μm in the subfoveal choroid, P<0.001).Eyes with HLA-B27-associated anterior uveitis showed significant choroidal thickening at acute phase that subsequently decreased after treatment, indicating subclinical choroidal inflammation in the eyes. Choroidal thickness might indicate disease activity in acute anterior uveitis associated with HLA-B27.http://europepmc.org/articles/PMC5489203?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Seong Joon Ahn
Ji Hong Kim
Byung Ro Lee
spellingShingle Seong Joon Ahn
Ji Hong Kim
Byung Ro Lee
Choroidal change in acute anterior uveitis associated with human leukocyte antigen-B27.
PLoS ONE
author_facet Seong Joon Ahn
Ji Hong Kim
Byung Ro Lee
author_sort Seong Joon Ahn
title Choroidal change in acute anterior uveitis associated with human leukocyte antigen-B27.
title_short Choroidal change in acute anterior uveitis associated with human leukocyte antigen-B27.
title_full Choroidal change in acute anterior uveitis associated with human leukocyte antigen-B27.
title_fullStr Choroidal change in acute anterior uveitis associated with human leukocyte antigen-B27.
title_full_unstemmed Choroidal change in acute anterior uveitis associated with human leukocyte antigen-B27.
title_sort choroidal change in acute anterior uveitis associated with human leukocyte antigen-b27.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2017-01-01
description To evaluate choroidal changes in eyes with acute anterior uveitis associated with human leukocyte antigen (HLA)-B27.In 44 patients with first-onset, unilateral, acute-onset (<1 week) anterior uveitis for which diagnostic work-ups revealed positivity only for HLA-B27, wide-field three-dimensional volumetric raster scan using swept-source optical coherence tomography was performed for both eyes. Choroidal thickness was measured by automated segmentation and thickness mapping and compared between eyes with uveitis and the fellow eyes at baseline. Choroidal thickness was compared before and after topical and/or systemic corticosteroid therapy. Relative choroidal thickening was defined as the choroidal thickness of the uveitic eye minus that of the corresponding eye and correlated with the degree of intraocular inflammation.Compared to the fellow eyes, eyes with acute anterior uveitis showed significant choroidal thickening on the subfoveal and parafoveal areas at baseline (all P <0.05). En face choroidal imaging showed dilation of large choroidal vessels on the macula. Relative choroidal thickening significantly correlated with the degree of anterior chamber inflammation at baseline (correlation coefficient = 0.341, P = 0.023). After treating inflammation, the choroid on the macula thinned significantly (from 262.1 ± 66.5 to 239.5 ± 61.0 μm in the subfoveal choroid, P<0.001).Eyes with HLA-B27-associated anterior uveitis showed significant choroidal thickening at acute phase that subsequently decreased after treatment, indicating subclinical choroidal inflammation in the eyes. Choroidal thickness might indicate disease activity in acute anterior uveitis associated with HLA-B27.
url http://europepmc.org/articles/PMC5489203?pdf=render
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