Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection

Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other pathological conditions and can potently suppress T-ce...

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Main Authors: Yan Wang, Xiaodong Gu, Jianbin Xiang, Zongyou Chen
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2012/731486
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spelling doaj-dce865ac614b43e2b9b646533d78e38d2020-11-24T23:47:49ZengHindawi LimitedClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/731486731486Myeloid-Derived Suppressor Cells Participate in Preventing Graft RejectionYan Wang0Xiaodong Gu1Jianbin Xiang2Zongyou Chen3Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, ChinaMyeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other pathological conditions and can potently suppress T-cell function. Here, we discuss recent findings that describe the molecular mechanisms of MDSCs suppressing T-cell immune responses as well as recent observations that MDSCs may have roles in transplant tolerance.http://dx.doi.org/10.1155/2012/731486
collection DOAJ
language English
format Article
sources DOAJ
author Yan Wang
Xiaodong Gu
Jianbin Xiang
Zongyou Chen
spellingShingle Yan Wang
Xiaodong Gu
Jianbin Xiang
Zongyou Chen
Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection
Clinical and Developmental Immunology
author_facet Yan Wang
Xiaodong Gu
Jianbin Xiang
Zongyou Chen
author_sort Yan Wang
title Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection
title_short Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection
title_full Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection
title_fullStr Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection
title_full_unstemmed Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection
title_sort myeloid-derived suppressor cells participate in preventing graft rejection
publisher Hindawi Limited
series Clinical and Developmental Immunology
issn 1740-2522
1740-2530
publishDate 2012-01-01
description Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other pathological conditions and can potently suppress T-cell function. Here, we discuss recent findings that describe the molecular mechanisms of MDSCs suppressing T-cell immune responses as well as recent observations that MDSCs may have roles in transplant tolerance.
url http://dx.doi.org/10.1155/2012/731486
work_keys_str_mv AT yanwang myeloidderivedsuppressorcellsparticipateinpreventinggraftrejection
AT xiaodonggu myeloidderivedsuppressorcellsparticipateinpreventinggraftrejection
AT jianbinxiang myeloidderivedsuppressorcellsparticipateinpreventinggraftrejection
AT zongyouchen myeloidderivedsuppressorcellsparticipateinpreventinggraftrejection
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