Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro
The authors form pre-epicardial cells (PECs) from hiPSC-derived lateral plate mesoderm on treating with BMP4, RA and VEGF, and co-culture these PECs with cardiomyocytes, inducing cardiomyocyte aggregation, proliferation and network formation with more mature structures and improved beating/contracti...
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Bibliographic Details
| Main Authors: |
Jun Jie Tan,
Jacques P. Guyette,
Kenji Miki,
Ling Xiao,
Gurbani Kaur,
Tong Wu,
Liye Zhu,
Katrina J. Hansen,
King-Hwa Ling,
David J. Milan,
Harald C. Ott |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-24921-z
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