Systemic dendrimer-drug nanomedicines for long-term treatment of mild-moderate cerebral palsy in a rabbit model

Systemic dendrimer-drug nanomedicines for long-term treatment of mild-moderate cerebral palsy in a rabbit model

Abstract Background Neuroinflammation mediated by microglia plays a central role in the pathogenesis of perinatal/neonatal brain injury, including cerebral palsy (CP). Therapeutics mitigating neuroinflammation potentially provide an effective strategy to slow the disease progression and rescue norma...

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Bibliographic Details
Main Authors: Zhi Zhang, Yi-An Lin, Soo-Young Kim, Lilly Su, Jinhuan Liu, Rangaramanujam M. Kannan, Sujatha Kannan
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Neuroinflammation
Subjects:
Cerebral palsy
Neuroinflammation
Microglia
Neurobehavior
PAMAM dendrimers
NAC
Online Access:http://link.springer.com/article/10.1186/s12974-020-01984-1

Internet

http://link.springer.com/article/10.1186/s12974-020-01984-1

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