The Oligopeptide Permease Opp Mediates Illicit Transport of the Bacterial P-site Decoding Inhibitor GE81112

The Oligopeptide Permease Opp Mediates Illicit Transport of the Bacterial P-site Decoding Inhibitor GE81112

GE81112 is a tetrapeptide antibiotic that binds to the 30S ribosomal subunit and specifically inhibits P-site decoding of the mRNA initiation codon by the fMet-tRNA anticodon. GE81112 displays excellent microbiological activity against some Gram-positive and Gram-negative bacteria in both minimal an...

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Bibliographic Details
Main Authors: Alessandro Maio, Letizia Brandi, Stefano Donadio, Claudio O. Gualerzi
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Antibiotics
Subjects:
peptide antibiotic
MIC
translation inhibitors
peptide transport
antibiotic resistance
cross resistance
Online Access:http://www.mdpi.com/2079-6382/5/2/17

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