Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD

Introduction and Hypothesis. Some papers have shown that bone mineral density (BMD) may not be accurate in predicting fracture risk. Recently microarchitecture parameters have been reported to give information on bone characteristics. The aim of this study was to find out if the values of volume, fr...

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Main Authors: Tomasz Topoliński, Adam Mazurkiewicz, Stanislaw Jung, Artur Cichański, Krzysztof Nowicki
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/2012/502781
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spelling doaj-dccc473d3ef147729f5ff284f975e6d72020-11-25T01:04:33ZengHindawi LimitedThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/502781502781Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMDTomasz Topoliński0Adam Mazurkiewicz1Stanislaw Jung2Artur Cichański3Krzysztof Nowicki4Faculty of Mechanical Engineering, University of Technology and Life Sciences, Kaliskiego 7 Street, 85-789 Bydgoszcz, PolandFaculty of Mechanical Engineering, University of Technology and Life Sciences, Kaliskiego 7 Street, 85-789 Bydgoszcz, PolandSouth Tyneside Hospital, South Shields, Tyne and Wear NE 34 OPL, UKFaculty of Mechanical Engineering, University of Technology and Life Sciences, Kaliskiego 7 Street, 85-789 Bydgoszcz, PolandFaculty of Mechanical Engineering, University of Technology and Life Sciences, Kaliskiego 7 Street, 85-789 Bydgoszcz, PolandIntroduction and Hypothesis. Some papers have shown that bone mineral density (BMD) may not be accurate in predicting fracture risk. Recently microarchitecture parameters have been reported to give information on bone characteristics. The aim of this study was to find out if the values of volume, fractal dimension, and bone mineral density are correlated with bone strength. Methods. Forty-two human bone samples harvested during total hip replacement surgery were cut to cylindrical samples. The geometrical mesh of layers of bone mass obtained from microCT investigation and the volumes of each layer and fractal dimension were calculated. The finite element method was applied to calculate the compression force F causing ε=0.8% strain. Results. There were stronger correlations for microarchitecture parameters with strength than those for bone mineral density. The values of determination coefficient R2 for mean volume and force were 0.88 and 0.90 for mean fractal dimension and force, while for BMD and force the value was 0.53. The samples with bigger mean bone volume of layers and bigger mean fractal dimension of layers (more complex structure) presented higher strength. Conclusion. The volumetric and fractal dimension parameters better describe bone structure and strength than BMD.http://dx.doi.org/10.1100/2012/502781
collection DOAJ
language English
format Article
sources DOAJ
author Tomasz Topoliński
Adam Mazurkiewicz
Stanislaw Jung
Artur Cichański
Krzysztof Nowicki
spellingShingle Tomasz Topoliński
Adam Mazurkiewicz
Stanislaw Jung
Artur Cichański
Krzysztof Nowicki
Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD
The Scientific World Journal
author_facet Tomasz Topoliński
Adam Mazurkiewicz
Stanislaw Jung
Artur Cichański
Krzysztof Nowicki
author_sort Tomasz Topoliński
title Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD
title_short Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD
title_full Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD
title_fullStr Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD
title_full_unstemmed Microarchitecture Parameters Describe Bone Structure and Its Strength Better Than BMD
title_sort microarchitecture parameters describe bone structure and its strength better than bmd
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2012-01-01
description Introduction and Hypothesis. Some papers have shown that bone mineral density (BMD) may not be accurate in predicting fracture risk. Recently microarchitecture parameters have been reported to give information on bone characteristics. The aim of this study was to find out if the values of volume, fractal dimension, and bone mineral density are correlated with bone strength. Methods. Forty-two human bone samples harvested during total hip replacement surgery were cut to cylindrical samples. The geometrical mesh of layers of bone mass obtained from microCT investigation and the volumes of each layer and fractal dimension were calculated. The finite element method was applied to calculate the compression force F causing ε=0.8% strain. Results. There were stronger correlations for microarchitecture parameters with strength than those for bone mineral density. The values of determination coefficient R2 for mean volume and force were 0.88 and 0.90 for mean fractal dimension and force, while for BMD and force the value was 0.53. The samples with bigger mean bone volume of layers and bigger mean fractal dimension of layers (more complex structure) presented higher strength. Conclusion. The volumetric and fractal dimension parameters better describe bone structure and strength than BMD.
url http://dx.doi.org/10.1100/2012/502781
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