Raman Evidence of p53-DBD Disorder Decrease upon Interaction with the Anticancer Protein Azurin

Raman Evidence of p53-DBD Disorder Decrease upon Interaction with the Anticancer Protein Azurin

Raman spectroscopy, which is a suitable tool to elucidate the structural properties of intrinsically disordered proteins, was applied to investigate the changes in both the structure and the conformational heterogeneity of the DNA-binding domain (DBD) belonging to the intrinsically disordered protei...

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Bibliographic Details
Main Authors: Sara Signorelli, Salvatore Cannistraro, Anna Rita Bizzarri
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
Raman spectroscopy
p53
intrinsically disordered protein
blue copper protein Azurin
protein–protein interaction
Amide I band deconvolution
principal component analysis
Online Access:https://www.mdpi.com/1422-0067/20/12/3078

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