The Cynomolgus Macaque Natural History Model of Pneumonic Tularemia for Predicting Clinical Efficacy Under the Animal Rule

The Cynomolgus Macaque Natural History Model of Pneumonic Tularemia for Predicting Clinical Efficacy Under the Animal Rule

Francisella tularensis is a highly infectious Gram-negative bacterium that is the etiologic agent of tularemia in animals and humans and a Tier 1 select agent. The natural incidence of pneumonic tularemia worldwide is very low; therefore, it is not feasible to conduct clinical efficacy testing of tu...

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Bibliographic Details
Main Authors: Tina Guina, Lynda L. Lanning, Kristian S. Omland, Mark S. Williams, Larry A. Wolfraim, Stephen P. Heyse, Christopher R. Houchens, Patrick Sanz, Judith A. Hewitt
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Francisella tularensis
pneumonic tularemia
cynomolgus macaque
non-human primate
animal model
Animal Rule
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2018.00099/full

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