Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling

Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling

Hypoxia is beneficial for the differentiation of stem cells transplanted for myocardial injury, but mechanisms underlying this benefit remain unsolved. Here, we report the impact of hypoxia-induced Jagged1 expression in cardiomyocytes (CMs) for driving the differentiation of cardiac stem cells (CSCs...

Full description

Bibliographic Details
Main Authors: Keke Wang, Ranran Ding, Yanping Ha, Yanan Jia, Xiaomin Liao, Sisi Wang, Rujia Li, Zhihua Shen, Hui Xiong, Junli Guo, Wei Jie
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Acta Pharmaceutica Sinica B
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383518300091

Similar Items

Similar Items