Myosin IIb activity and phosphorylation status determines dendritic spine and post-synaptic density morphology.

Myosin IIb activity and phosphorylation status determines dendritic spine and post-synaptic density morphology.

Dendritic spines in hippocampal neurons mature from a filopodia-like precursor into a mushroom-shape with an enlarged post-synaptic density (PSD) and serve as the primary post-synaptic location of the excitatory neurotransmission that underlies learning and memory. Using myosin II regulatory mutants...

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Bibliographic Details
Main Authors: Jennifer L Hodges, Karen Newell-Litwa, Hannelore Asmussen, Miguel Vicente-Manzanares, Alan Rick Horwitz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3162601?pdf=render

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