Pitfalls in experimental designs for characterizing the transcriptional, methylational and copy number changes of oncogenes and tumor suppressor genes.

Pitfalls in experimental designs for characterizing the transcriptional, methylational and copy number changes of oncogenes and tumor suppressor genes.

BACKGROUND: It is a common practice that researchers collect a set of samples without discriminating the mutants and their wild-type counterparts to characterize the transcriptional, methylational and/or copy number changes of pre-defined candidate oncogenes or tumor suppressor genes (TSGs), althoug...

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Bibliographic Details
Main Authors: Yuannv Zhang, Jiguang Xia, Yujing Zhang, Yao Qin, Da Yang, Lishuang Qi, Wenyuan Zhao, Chenguang Wang, Zheng Guo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3589351?pdf=render

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