Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers

Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers

Pharmaceutical reactivation of lytic cycle of Epstein⁻Barr virus (EBV) represents a potential therapeutic strategy against EBV-associated epithelial malignancies, e.g., gastric carcinoma (GC) and nasopharyngeal carcinoma (NPC). A novel lytic-inducing compound, C7, which exhibits structural...

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Bibliographic Details
Main Authors: Stephanie Pei Tung Yiu, Kwai Fung Hui, Chung King Choi, Richard Yi Tsun Kao, Chi Wang Ma, Dan Yang, Alan Kwok Shing Chiang
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cancers
Subjects:
iron chelation
Epstein–Barr virus
lytic cycle
gastric carcinoma
nasopharyngeal carcinoma
autophagy
Online Access:https://www.mdpi.com/2072-6694/10/12/505

Internet

https://www.mdpi.com/2072-6694/10/12/505

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