MEDICI: Mining Essentiality Data to Identify Critical Interactions for Cancer Drug Target Discovery and Development.

MEDICI: Mining Essentiality Data to Identify Critical Interactions for Cancer Drug Target Discovery and Development.

Protein-protein interactions (PPIs) mediate the transmission and regulation of oncogenic signals that are essential to cellular proliferation and survival, and thus represent potential targets for anti-cancer therapeutic discovery. Despite their significance, there is no method to experimentally dis...

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Bibliographic Details
Main Authors: Sahar Harati, Lee A D Cooper, Josue D Moran, Felipe O Giuste, Yuhong Du, Andrei A Ivanov, Margaret A Johns, Fadlo R Khuri, Haian Fu, Carlos S Moreno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5261804?pdf=render

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http://europepmc.org/articles/PMC5261804?pdf=render

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