The Transcription Factor ZNF683/HOBIT Regulates Human NK-Cell Development

The Transcription Factor ZNF683/HOBIT Regulates Human NK-Cell Development

We identified ZNF683/HOBIT as the most highly upregulated transcription factor gene during ex vivo differentiation of human CD34+ cord blood progenitor cells to CD56+ natural killer (NK) cells. ZNF683/HOBIT mRNA was preferentially expressed in NK cells compared to other human peripheral blood lympho...

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Bibliographic Details
Main Authors: Mirte Post, Angelica Cuapio, Markus Osl, Dorit Lehmann, Ulrike Resch, David M. Davies, Martin Bilban, Bernhard Schlechta, Wolfgang Eppel, Amit Nathwani, Dagmar Stoiber, Jan Spanholtz, Emilio Casanova, Erhard Hofer
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
ZNF683/HOBIT
natural killer cells
CD56
ex vivo differentiation
NK-cell development
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00535/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00535/full

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