Assessment of immunoglobulin G antibodies against oxidized low-density lipoproteins in patients with acute coronary syndrome

• Main Authors: Mohamed S Mokhtar, Hanan Zaghla, Wael Samy, Abdou Mahmoud
• Format: Article
• Language: English
• Published: SpringerOpen 2013-01-01
• Series: The Egyptian Journal of Internal Medicine
• Subjects: Acute coronary syndrome, low-density lipoprotein antibodies, Immunoglobulin G
• Online Access: http://www.esim.eg.net/article.asp?issn=1110-7782;year=2013;volume=25;issue=4;spage=177;epage=184;aulast=Mokhtar

Background Oxidative modification of low-density lipoproteins (LDLs) induces formation of immunogenic epitopes in the LDL molecule, which leads to the formation of antibodies against oxidized low-density lipoprotein (OxLDL) that can be detected in serum. Aim of the study The objective of this study was to evaluate the association between autoantibodies against OxLDL and acute coronary syndrome (ACS). Patients and methods A total of 50 patients diagnosed as having ACS (37 male patients and 13 female patients), age ranging between 19 and 82 years and admitted to the critical care department, Cairo University, and 19 matched healthy controls were enrolled in our study. All patients were subjected to detailed medical history-taking and physical examination, serial 12-lead ECGs, serial cardiac biomarkers on admission and 24 h later, echocardiography, coronary angiography and assessement of severity using the Gensini score, and IgG anti-OxLDL antibodies measurement. Results We found significant difference in the level of antibody between patients with ACS and matched healthy controls (P < 0.001). With respect to the correlation of anti-OxLDL antibodies and the severity of ACS, we found significant correlation between the level of antibodies in patients with ACS as assessed by the Gensini score (r = 0.709) as well as between the echocardiographic findings as assessed by the wall motion score index (r = 0.589). During hospitalization, there was significant correlation of the antibody level with mechanical complications (P = 0.047) and needed immediate intervention (P < 0.001). However, the antibody level was correlated with malignant arrhythmias but P value (0.219) was insignificant because of high SD, and there was no correlation with ischemic complications (P = 0.798). Conclusion With respect to the correlation of anti-OxLDL antibodies and ACS, the patients with ACS had higher anti-OxLDL antibodies level. In addition, anti-OxLDL antibodies level was correlated with the Gensini score, wall motion score index, and major adverse cardiovascular events during hospitalization.