EFFECT OF IRON AND SELENIUM DRUGS ON DIASTOLIC MYOCARDIAL FUNCTION IN PATIENTS WITH ANEMIC CARDIOMYOPATHY

• Main Authors: E. V. Goncharova, A. V. Govorin
• Format: Article
• Language: English
• Published: Stolichnaya Izdatelskaya Kompaniya 2015-09-01
• Series: Racionalʹnaâ Farmakoterapiâ v Kardiologii
• Subjects: анемическая кардиомиопатия; сегментарная диастолическая функция; препараты железа; препараты селена
• Online Access: http://www.rpcardio.ru/jour/article/view/81
• ISSN: 1819-6446; 2225-3653

<p>Aim. To study the changes of the left (LV) and right (RV) ventricles diastolic function, the segmental LV diastolic function in patients with anemic cardiomyopathy after the iron and selenium drugs therapy.<br />Material and methods. Patients (n=54) with severe chronic post-hemorrhagic iron deficiency anemia, complicated by cardiomyopathy were treated with iron sulfate and sele- nium. Segmental LV diastolic function was evaluated with pulsed tissue Doppler, and global diastolic function of the LV and RV – with Doppler echocardiography, before and af- ter treatment. Control group contained 16 healthy individuals<br />Results. Disorders of segmental LV diastolic function, and both ventricles global diastolic function were found in anemic patients with cardiomyopathy. Flow rate rapid filling re- duced by 27.1% compared with this in control (p&lt;0.001), and flow rate of atrial filling increased by 27.0% (p&lt;0.001), and E/A decreased by 42.2% (p&lt;0.001). Iron and se- lenium therapy in patients with anemic cardiomyopathy led to an improvement in diastolic function. LV and RV flow rapid filling increased by 32.2% (p&lt;0.001) and 8.3% (p&lt;0.05), respectively, and LV and RV flow rate of atrial filling reduced by 19.6% and 15.7% (p&lt;0.001), respectively, and LV and RV E/A ratio grew up by 61.5% and 28.2%, respective- ly (p&lt;0.001).<br />Conclusion. Echocardiography and myocardial tissue Doppler provide early finding of segmental LV diastolic function disorders in anemic cardiomyopathy. Iron and selenium ther- apy leads to improvement of myocardial diastolic function in these patients.</p>