MCU-Dependent mROS Generation Regulates Cell Metabolism and Cell Death Modulated by the AMPK/PGC-1α/SIRT3 Signaling Pathway

MCU-Dependent mROS Generation Regulates Cell Metabolism and Cell Death Modulated by the AMPK/PGC-1α/SIRT3 Signaling Pathway

The mitochondrial calcium uniporter is an intensively investigated calcium channel, and its molecular components, structural features, and encoded genes have long been explored. Further studies have shown that the mitochondrial calcium unidirectional transporter (MCU) is a macromolecular complex rel...

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Bibliographic Details
Main Authors:	Yuxin Wang, Xiang Li, Fengchao Zhao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-07-01
Series:	Frontiers in Medicine
Subjects:	mitochondrial calcium uniporter mitochondrial reactive oxygen species metabolism AMPK/PGC-1α/SIRT3 cell death
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2021.674986/full

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