The positive role of vitronectin in radiation induced lung toxicity: the in vitro and in vivo mechanism study

The positive role of vitronectin in radiation induced lung toxicity: the in vitro and in vivo mechanism study

Abstract Background Radiation-induced lung toxicity (RILT) is a severe complication of radiotherapy in patients with thoracic tumors. Through proteomics, we have previously identified vitronectin (VTN) as a potential biomarker for patients with lung toxicity of grade ≥ 2 radiation. Herein, we explor...

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Bibliographic Details
Main Authors: Tian-Le Shen, Mi-Na Liu, Qin Zhang, Wen Feng, Wen Yu, Xiao-Long Fu, Xu-Wei Cai
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Translational Medicine
Subjects:
Radiation therapy
Radiation induced lung fibrosis
Vitronectin
Fibroblasts
TGF-β
Online Access:http://link.springer.com/article/10.1186/s12967-018-1474-y

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